Bone augmentation in rabbit tibia using microfixed cobalt-chromium membranes with whole blood, tricalcium phosphate and bone marrow cells
Identifieur interne : 001371 ( Main/Exploration ); précédent : 001370; suivant : 001372Bone augmentation in rabbit tibia using microfixed cobalt-chromium membranes with whole blood, tricalcium phosphate and bone marrow cells
Auteurs : Oscar Decco ; Andrea Cura ; Víctor Beltrán [Allemagne, Chili] ; María Lezcano ; Wilfried Engelke [Allemagne]Source :
- International Journal of Clinical and Experimental Medicine [ 1940-5901 ] ; 2015.
Abstract
To assess bone augmentation based on a non-critical defect, 1.5 mm deep cobalt-chromium (Co-Cr) barrier membranes were placed on seven adult California rabbits with three different grafting situations: whole blood, whole blood with tricalcium phosphate (TCP), and TCP mixed with bone marrow cells. Macroscopic assessment of the animals was performed once a week and densitometric studies were performed once a month. Three months post-surgery, after detaching the membranes, tibias were sectioned and followed the routine laboratory processing for decalcified sections, with inclusion in paraffin and staining by hematoxylin and eosin technique. Bone augmentation was observed for each animal, even sometimes over the Co-Cr membranes. Compact bone was mostly observed for every situation, with a higher cellular activity on those samples with bone grafts. This could be due to the presence of graft remains at the growth area. It could be concluded that blood supply to the site providing growth factors by the blood clot formation, and the placement of an osteoconductive non-resolvable membrane that favors osseoinduction, may be sufficient elements to achieve bone augmentation in a period of three months in rabbit tibia.
Url:
PubMed: 25784982
PubMed Central: 4358437
Affiliations:
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Rios</institution><addr-line>Argentina</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cura, Andrea" sort="Cura, Andrea" uniqKey="Cura A" first="Andrea" last="Cura">Andrea Cura</name><affiliation><nlm:aff id="au1"><institution>Department of Bioengineering, Faculty of Engineering, Universidad Nacional de Entre Rios</institution><addr-line>Argentina</addr-line></nlm:aff></affiliation></author><author><name sortKey="Beltran, Victor" sort="Beltran, Victor" uniqKey="Beltran V" first="Víctor" last="Beltrán">Víctor Beltrán</name><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Oral and Maxillofacial Surgery, Georg-August-University Hospital</institution><addr-line>Göttingen, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Göttingen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au3"><institution>CIMOFIR Research Center, Faculty of Dentistry, Universidad de La 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level="j">International Journal of Clinical and Experimental Medicine</title><idno type="eISSN">1940-5901</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>To assess bone augmentation based on a non-critical defect, 1.5 mm deep cobalt-chromium (Co-Cr) barrier membranes were placed on seven adult California rabbits with three different grafting situations: whole blood, whole blood with tricalcium phosphate (TCP), and TCP mixed with bone marrow cells. Macroscopic assessment of the animals was performed once a week and densitometric studies were performed once a month. Three months post-surgery, after detaching the membranes, tibias were sectioned and followed the routine laboratory processing for decalcified sections, with inclusion in paraffin and staining by hematoxylin and eosin technique. Bone augmentation was observed for each animal, even sometimes over the Co-Cr membranes. Compact bone was mostly observed for every situation, with a higher cellular activity on those samples with bone grafts. This could be due to the presence of graft remains at the growth area. It could be concluded that blood supply to the site providing growth factors by the blood clot formation, and the placement of an osteoconductive non-resolvable membrane that favors osseoinduction, may be sufficient elements to achieve bone augmentation in a period of three months in rabbit tibia.</p></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Chili</li></country></list><tree><noCountry><name sortKey="Cura, Andrea" sort="Cura, Andrea" uniqKey="Cura A" first="Andrea" last="Cura">Andrea Cura</name><name sortKey="Decco, Oscar" sort="Decco, Oscar" uniqKey="Decco O" first="Oscar" last="Decco">Oscar Decco</name><name sortKey="Lezcano, Maria" sort="Lezcano, Maria" uniqKey="Lezcano M" first="María" last="Lezcano">María Lezcano</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Beltran, Victor" sort="Beltran, Victor" uniqKey="Beltran V" first="Víctor" last="Beltrán">Víctor Beltrán</name></noRegion><name sortKey="Engelke, Wilfried" sort="Engelke, Wilfried" uniqKey="Engelke W" first="Wilfried" last="Engelke">Wilfried Engelke</name></country><country name="Chili"><noRegion><name sortKey="Beltran, Victor" sort="Beltran, Victor" uniqKey="Beltran V" first="Víctor" last="Beltrán">Víctor Beltrán</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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